Osteosarcoma – conventional treatment vs. gene therapy

Literature Highlight: Surgical vs Conventional Therapy for Weight Loss Treatment of Obstructive Sleep Apnea

A two-year, randomized, controlled trial attempted to determine if surgically-induced weight loss was more effective than weight loss from conventional therapy for management of OSA. Patients had a BMI between 35 and 55 kg/m, an apnea-hypopnea index (AHI) of >20 events, a recent diagnosis of OSA with recommendations to begin CPAP therapy, and at least three prior significant weight loss attempt...

Surgical vs conventional therapy for weight loss treatment of obstructive sleep apnea: a randomized controlled trial.

CONTEXT Obstructive sleep apnea (OSA) is strongly related to obesity. Weight loss is recommended as part of the overall management plan for obese patients diagnosed with OSA. OBJECTIVE To determine whether surgically induced weight loss is more effective than conventional weight loss therapy in the management of OSA. DESIGN, SETTING, AND PATIENTS A randomized controlled trial of 60 obese pa...

Clinical investigations in the treatment of meningeal leukemia: radiation therapy regimens vs. conventional intrathecal methotrexate.

Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models.

Osteocalcin (OC), a noncollagenous bone matrix protein, is expressed in high levels by osteoblasts. To determine whether the OC promoter mediates cell-specific gene expression in cells of osteoblast lineage, we constructed a recombinant adenovirus, Ad-OC-TK, which contains the OC promoter that drives the expression of herpes simplex virus thymidine kinase (TK). We tested the expression of TK by...

Cognitive Behavioral Therapy Treatment Approach: Group Therapy vs. Individual Therapy

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